File --> Setup --> General --> User Level--> Email --> Set Inbox Options
- CHECK the box, "Check for new messages every ___ minutes".
- CHECK the box, "Start Mail Agent at System Setup".
- This will UnGray "Out of the Office". Click on the "Out of the Office Tab".
- CHECK the box, "Enable Out of the Office Responder".
You can now setup the subject and the email for your out of office message. This is much easier then setting it up in outlook.